The Effects of Anti-aging Protein, Klotho, on Skeletal Muscle
نویسندگان
چکیده
منابع مشابه
Skeletal muscle as a regulator of the longevity protein, Klotho
Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association between muscle function and Klotho expression has been previously suggested from longitudinal cohort studies, a direct relationship between circulating K...
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Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training. Materials and Met...
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Background and Objectives: Different diets have important roles in human health and aging. In the current study, we aimed to characterize the Klotho, an anti-aging protein, gene expression and protein level in the serum and assess the protein levels of Transforming growth factor-β and Platelet-derived growth factor in old rats which treated with different diets (high-fat, high-protein, low calo...
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Klotho is an anti-aging single-pass membrane protein that is mainly produced in the kidney. The level of soluble klotho decreases with age and the klotho gene is associated with an increased risk of age-related diseases, such as diabetes, skin atrophy, chronic kidney disease, ataxia and cancer. The klotho gene is composed of five exons and encodes a membrane glycoprotein located in the plasma ...
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Introduction: exercise interventions can play an important role in delaying aging. Klotho protein and Growth Differentiation Factor 11 (GDF11) are a new family of biochemical theories of the aging process. The aim of the present study was to investigate the effect of 12 weeks of resistance training on serum levels of Klotho anti-aging proteins and rejuvenating of GDF11 factor in elderly men. Me...
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